Site-Selective DNA Photocleavage Involving Unusual Photoinitiated Tautomerization of Chiral Tridentate Vanadyl(V) Complexes Derived from N-Salicylidene α-Amino Acids

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Title:	Site-Selective DNA Photocleavage Involving Unusual Photoinitiated Tautomerization of Chiral Tridentate Vanadyl(V) Complexes Derived from N-Salicylidene α-Amino Acids
Authors:	Chen, Chien-tien;Lin, Jin-sheng;Kuo, Jen-huang;Weng, Shiue-shien;Cuo, Ting-shen;Lin, Yi-wen;鄭建中;Cheng, Chien-chung;Huang, Yan-chen;Yu, Jen-kan;Chou, Pi-tai
Contributors:	淡江大學化學學系
Date:	2004-11-25
Issue Date:	2009-12-01
Publisher:	American Chemical Society (ACS)
Abstract:	The titled vanadyl(V) complexes serve as efficient reagents for cleaving supercoiled plasmid DNA by photoinitiation. Complex 3d, derived from 2-hydroxy-1-naphthaldehyde and l-phenylalanine, exhibits a unique wedge feature, inducing a site-selective photocleavage at the C22-T23 of the bulge backbone for a HIV-27 DNA system at 0.1−5 μM. Transient absorption experiments for 3d indicate the involvement of LMCT with concomitant tautomerization, leading to an o-quinone-methide V-bound hydroxyl species responsible for the cleavage profiles.
Relation:	Organic letters 6(24), pp.4471-4474
DOI:	10.1021/ol048156h
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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