Probing the interaction of kojic acid antibiotics with iron(III) chloride by using electrospray tandem mass spectrometry

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Title:	Probing the interaction of kojic acid antibiotics with iron(III) chloride by using electrospray tandem mass spectrometry
Authors:	Sudhir, Putty-reddy;Wu, Hui-fen;Zhou, Zi-cong
Contributors:	淡江大學化學學系
Date:	2005-01
Issue Date:	2013-06-07 10:32:16 (UTC+8)
Publisher:	West Sussex: John Wiley & Sons Ltd.
Abstract:	Kojic acid, 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, has been used extensively as a clinical iron-chelating drug although the nature of the complexes of iron and kojic acid has not been established. In this article we demonstrate the complexation of kojic acid with iron(III) chloride by using electrospray ionization mass spectrometry (ESI-MS). The ESI-MS analysis revealed different reactions between iron(III) chloride and kojic acid (M), and the mass spectrum exhibited four complexes: [Fe+2(M[BOND]H)]+, [Fe+3(M[BOND]H)+H]+, [Fe2+4(M[BOND]H)+Cl]+, and [Fe2+5(M[BOND]H)]+. All these proposed complexes and the presence of chloride ion in one of the dinuclear complexes have been confirmed by isotopic patterns and fragmentation studies by means of tandem mass spectrometry (MSn). Copyright © 2004 John Wiley & Sons, Ltd.
Relation:	Rapid Communications in Mass Spectrometry 19(2), pp.209-212
DOI:	10.1002/rcm.1773
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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