A disaccharide, Glcβ(1→3)GlcNAcβ1→Stol (GGS, 1), was synthesized and demonstrated to stabilize ct-DNA during the denaturing process. GGS at 50 μM shifted Tm of ct-DNA by 23 °C and the behavior was pH dependent. Poly(dA-dT)2 was found to be the preferable type of DNA for GGS stabilization by circular dichroism spectroscopy study.
Relation:
Journal of the Chinese Chemical Society=中國化學會會誌 51(3), pp.655-658
