Novel design of a pentacyclic scaffold as structural mimic of saframycin A

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Title:	Novel design of a pentacyclic scaffold as structural mimic of saframycin A
Authors:	Ong, Chi-wi;Chang, Yu-an;Wu, Jing-yun;Cheng, Chien-chung;鄭建中
Contributors:	淡江大學化學學系
Keywords:	5a,12a-diazapentacene;saframycin model;DNA binding and scissioning
Date:	2003-10-06
Issue Date:	2009-12-01
Publisher:	Elsevier
Abstract:	The design, synthesis and evaluation of a pentacyclic scaffold, CWO-324 to mimic saframycin A is described. CWO-324 is readily synthesized in five steps from 1,4-diacetyl-piperazine-2,5-dione and 2,5-dimethoxybenzaldehyde. CWO-324 was found to scission DNA, binds to bases 69–83(5′-GCAGTCAGG CACCGT-3′) of Hind III/Rsa I from plasmid pBR322 DNA in a foot-printing study and possesses anti-tumor activity.
Relation:	Tetrahedron 59(41), pp.8245-8249
DOI:	10.1016/j.tet.2003.08.036
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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