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    題名: Novel design of a pentacyclic scaffold as structural mimic of saframycin A
    作者: Ong, Chi-wi;Chang, Yu-an;Wu, Jing-yun;Cheng, Chien-chung;鄭建中
    貢獻者: 淡江大學化學學系
    關鍵詞: 5a,12a-diazapentacene;saframycin model;DNA binding and scissioning
    日期: 2003-10-06
    上傳時間: 2009-12-01
    出版者: Elsevier
    摘要: The design, synthesis and evaluation of a pentacyclic scaffold, CWO-324 to mimic saframycin A is described. CWO-324 is readily synthesized in five steps from 1,4-diacetyl-piperazine-2,5-dione and 2,5-dimethoxybenzaldehyde. CWO-324 was found to scission DNA, binds to bases 69–83(5′-GCAGTCAGG CACCGT-3′) of Hind III/Rsa I from plasmid pBR322 DNA in a foot-printing study and possesses anti-tumor activity.
    關聯: Tetrahedron 59(41), pp.8245-8249
    DOI: 10.1016/j.tet.2003.08.036
    顯示於類別:[化學學系暨研究所] 期刊論文

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