English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 52047/87178 (60%)
造訪人次 : 8691975      線上人數 : 168
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/25108

    題名: Novel design of a pentacyclic scaffold as structural mimic of saframycin A
    作者: Ong, Chi-wi;Chang, Yu-an;Wu, Jing-yun;Cheng, Chien-chung;鄭建中
    貢獻者: 淡江大學化學學系
    關鍵詞: 5a,12a-diazapentacene;saframycin model;DNA binding and scissioning
    日期: 2003-10-06
    上傳時間: 2009-12-01
    出版者: Elsevier
    摘要: The design, synthesis and evaluation of a pentacyclic scaffold, CWO-324 to mimic saframycin A is described. CWO-324 is readily synthesized in five steps from 1,4-diacetyl-piperazine-2,5-dione and 2,5-dimethoxybenzaldehyde. CWO-324 was found to scission DNA, binds to bases 69–83(5′-GCAGTCAGG CACCGT-3′) of Hind III/Rsa I from plasmid pBR322 DNA in a foot-printing study and possesses anti-tumor activity.
    關聯: Tetrahedron 59(41), pp.8245-8249
    DOI: 10.1016/j.tet.2003.08.036
    顯示於類別:[化學學系暨研究所] 期刊論文


    檔案 描述 大小格式瀏覽次數



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋