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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/25050


    Title: Metal Ion Dependent Binding and Nuclease Activity of Hexaazacyclophane
    Authors: Chang, Tsu-hsin;Ong, Chi-wi;Chou, Yi-meen;Chung, Kuo-shen;王文竹;Wang, Wen-jwu
    Contributors: 淡江大學化學學系
    Keywords: HAPP-Cu;HAPP-Fe;DNA binding affinity;DNA cleavage
    Date: 1996-02
    Issue Date: 2009-12-01
    Publisher: 中國化學會
    Abstract: The HAPP-Fe complex was more active than HAPP-Cu complex in cleavage of DNA in the presence of dithiothreitol and hydrogen peroxide. In contrast, the HAPP-Cu complex was found to bind more strongly with λ-DNA, whereas the HAPP-Fe binds weakly. It was shown that the metal ion complexed with HAPP ligand can influence the binding and cleaving activity due to the ability of the ligand to undergo geometrical tautomerization.
    Relation: Journal of the Chinese Chemical Society 43(1), pp.72-75
    DOI: 10.1002/jccs.199600012
    Appears in Collections:[化學學系暨研究所] 期刊論文

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