The HAPP-Fe complex was more active than HAPP-Cu complex in cleavage of DNA in the presence of dithiothreitol and hydrogen peroxide. In contrast, the HAPP-Cu complex was found to bind more strongly with λ-DNA, whereas the HAPP-Fe binds weakly. It was shown that the metal ion complexed with HAPP ligand can influence the binding and cleaving activity due to the ability of the ligand to undergo geometrical tautomerization.
Relation:
Journal of the Chinese Chemical Society 43(1), pp.72-75
