Marchantinquinone, isolated from Reboulia hemisphaerica, as inhibitor of lipid peroxidation and as free radical scavenger

doi:10.1016/0009-2797(95)03641-5

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/25040

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题名:	Marchantinquinone, isolated from Reboulia hemisphaerica, as inhibitor of lipid peroxidation and as free radical scavenger
作者:	Ko, F. N.;Liao, C. H.;吳嘉麗;Wu, Chia-li
贡献者:	淡江大學化學學系
关键词:	Antioxidant;Lipid peroxidation;Marchantinquinone;Reboulia hemisphaerica;Free radical
日期:	1995-11-17
上传时间:	2009-12-01
出版者:	Elsevier
摘要:	The antioxidant effect of marchantinquinone was studied using various models. Marchantinquinone inhibited Fe2+-induced lipid peroxidation in rat brain homogenate in a concentration-dependent manner with an IC50 15.3 ± 2.9 μM. Marchantinquinone was less effective than α-tocopherol and BHT in reducing the stable free radical diphenyl-2-picrylhydrazyl (DPPH). The IC0.200 were 37.5 ± 2.5, 9.2 ± 1.6 and 14.5 ± 2.5 μM, respectively. Marchantinquinone also scavenged peroxyl radical derived from 2,2′-azobis(2-amidinopropane)dihydrochloride (AAPH) in aqueous system with a stoichiometric factor of 0.9 ± 0.1. Furthermore, it prevented conjugated-diene formation and apolipoprotein B (apo B) oxidation of LDL. However, marchantinquinone did not chelate Fe2+ or possess Superoxide anion and hydroxyl radical scavenging activity. It also did not scavenge 2,2′-azobis(2,4-dimethylvaleronitrile) (AMVN)-derived peroxyl radical in hexane. These results indicate that marchantinquinone may be an effective antioxidant and can protect rat brain homogenate and LDL against oxidation.
關聯:	Chemico-biological interactions 98(2), pp.131-143
DOI:	10.1016/0009-2797(95)03641-5
显示于类别:	[化學學系暨研究所] 期刊論文

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