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    Title: Marchantinquinone, isolated from Reboulia hemisphaerica, as inhibitor of lipid peroxidation and as free radical scavenger
    Authors: Ko, F. N.;Liao, C. H.;吳嘉麗;Wu, Chia-li
    Contributors: 淡江大學化學學系
    Keywords: Antioxidant;Lipid peroxidation;Marchantinquinone;Reboulia hemisphaerica;Free radical
    Date: 1995-11-17
    Issue Date: 2009-12-01
    Publisher: Elsevier
    Abstract: The antioxidant effect of marchantinquinone was studied using various models. Marchantinquinone inhibited Fe2+-induced lipid peroxidation in rat brain homogenate in a concentration-dependent manner with an IC50 15.3 ± 2.9 μM. Marchantinquinone was less effective than α-tocopherol and BHT in reducing the stable free radical diphenyl-2-picrylhydrazyl (DPPH). The IC0.200 were 37.5 ± 2.5, 9.2 ± 1.6 and 14.5 ± 2.5 μM, respectively. Marchantinquinone also scavenged peroxyl radical derived from 2,2′-azobis(2-amidinopropane)dihydrochloride (AAPH) in aqueous system with a stoichiometric factor of 0.9 ± 0.1. Furthermore, it prevented conjugated-diene formation and apolipoprotein B (apo B) oxidation of LDL. However, marchantinquinone did not chelate Fe2+ or possess Superoxide anion and hydroxyl radical scavenging activity. It also did not scavenge 2,2′-azobis(2,4-dimethylvaleronitrile) (AMVN)-derived peroxyl radical in hexane. These results indicate that marchantinquinone may be an effective antioxidant and can protect rat brain homogenate and LDL against oxidation.
    Relation: Chemico-biological interactions 98(2), pp.131-143
    DOI: 10.1016/0009-2797(95)03641-5
    Appears in Collections:[化學學系暨研究所] 期刊論文

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