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    題名: Knockdown of zebrafish Nav1.6 sodium channel impairs embryonic locomotor activities
    作者: 陳曜鴻;Chen, Yau-hung;Huang, F. L.;Cheng, Y. C.;Wu, C. J.;Yang, C. N.;Tsay, H. J.
    貢獻者: 淡江大學生命科學研究所
    關鍵詞: zebrafish;sodium channel;morpholino;locomotor activities
    日期: 2008-01
    上傳時間: 2009-11-05 16:37:58 (UTC+8)
    出版者: Karger
    摘要: Although multiple subtypes of sodium channels are expressed in most neurons, the specific contributions of the individual sodium channels remain to be studied. The role of zebrafish Nav1.6 sodium channels in the embryonic locomotor movements has been investigated by the antisense morpholino (MO) knockdown. MO1 and MO2 are targeted at the regions surrounding the translation start site of zebrafish Nav1.6 mRNA. MO3 is targeted at the RNA splicing donor site of exon 2. The correctly spliced Nav1.6 mRNA of MO3 morphants is 6% relative to that of the wild-type embryos. Nav1.6-targeted MO1, MO2 and MO3 attenuate the spontaneous contraction, tactile sensitivity, and swimming in comparison with a scrambled morpholino and mutated MO3 morpholino. No significant defect is observed in the development of slow muscles, the axonal projection of primary motoneurons, and neuromuscular junctions. The movement impairments caused by MO1, MO2, and MO3 suggest that the function of Nav1.6 sodium channels is essential on the normal early embryonic locomotor activities.
    關聯: Journal of Biomedical Science 15(1), pp.69-78
    DOI: 10.1007/s11373-007-9200-4
    顯示於類別:[化學學系暨研究所] 期刊論文

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