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    Title: A facile synthesis of 1-ethoxy-4-cyano-5-ethoxycarbonyl-3H-azuleno[1,2-c]pyran-3-one, a selective 15-lipoxygenase inhibitor
    Authors: Lin, Bing-bing;Morita, Tadayoshi;Lin, Yun-shan;Chen, Hui-ling
    Contributors: 淡江大學化學學系
    Date: 2004-01-05
    Issue Date: 2009-11-04 16:51:38 (UTC+8)
    Publisher: Kidlington: Pergamon Press
    Abstract: A facile method to synthesize 1-ethoxy-4-cyano-5-ethoxycarbonyl-3H-azuleno[1,2-c]pyran-3-one, in yield of 92%, which showed selective inhibition effect on 15-lipoxygenase(soybean source) at IC50=24.2 2.7 mM while no inhibition effect was observed at greater than 300 mM on 5-lipoxygenase, lipid peroxidase, phospholipase A2, protein kinase C, and cyclooxygenase.
    Relation: Bioorganic Medicinal Chemistry Letters 14(1), pp.63-65
    DOI: 10.1016/j.bmcl.2003.10.012
    Appears in Collections:[化學學系暨研究所] 期刊論文

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