資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/127655
|
| 題名: | New record of potential tyrosinase inhibitory, antioxidant and photoprotective effects of Vietnamese Castanea mollissima extracts |
| 作者: | Vu, Thi Thu Le;Wang, San-Lang;Luc, Quang Tan;Do, Tien Lam;Dam, Thi Bich Hanh;Phan, Thi Kim Phung;Nguyen, Thanh Thao;Tran, Phuc Hoang;Nguyen, Anh Dzung;Nguyen, Van Bon |
| 關鍵詞: | Castanea mollissima;antioxidants;cosmetics;photoprotective agents;tyrosinase inhibitor |
| 日期: | 2025-04-23 |
| 上傳時間: | 2025-08-29 12:05:11 (UTC+8) |
| 摘要: | In this study, the potential anti-tyrosinase, antioxidant, and ultraviolet (UV) absorption efficiency of the extracts of different parts of Castanea mollissima were evaluated. The leaf extract exhibited the most potential antioxidant effect with 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging abilities of >90%. C. mollissima extracts showed high UV-A and UV-B absorption efficiency. In addition, screening of the leaf extract demonstrated C. mollissima leaves as a rich source of tyrosinase inhibitors with maximum inhibitory activity and half-maximal inhibitory concentration values of 96% and 336.43 µg/mL, respectively. This is the first-ever report of screening of leaf extract for its potential activities. Eighteen phyto-compounds were identified from the C. mollissima leaf extract using gas chromatography-mass spectrometry and high-performance liquid chromatography techniques. Of these, the content of compounds 10, 11, 12, 13, 14, and 16 in the C. mollissima leaf extract was significantly high (14.35-88.42 µg/g). The molecular docking, absorption, distribution, metabolism, excretion, and toxicity, and Lipinski's rule of five analyses indicated high interaction efficacy of all the major compounds (docking score values of -6.75 to -8.89 kcal/mol) with the target enzyme tyrosinase, had drug properties, and were non-toxic for human use. |
| 關聯: | Chemistry & Biodiversity, e202500994 |
| DOI: | 10.1002/cbdv.202500994 |
| 顯示於類別: | [化學學系暨研究所] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 161 | 檢視/開啟 |
|
在機構典藏中所有的資料項目都受到原著作權保護.
|
