New record of potential tyrosinase inhibitory, antioxidant and photoprotective effects of Vietnamese Castanea mollissima extracts

doi:10.1002/cbdv.202500994

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/127321

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題名:	New record of potential tyrosinase inhibitory, antioxidant and photoprotective effects of Vietnamese Castanea mollissima extracts
作者:	Wang, San-lang
日期:	2025-04-23
上傳時間:	2025-04-28 12:05:37 (UTC+8)
出版者:	Wiley
摘要:	In this study, the potential anti-tyrosinase, antioxidant, and UV absorption efficiency of the extracts of different parts of Castanea mollissima were evaluated. The leaf extract exhibited the most potential antioxidant effect with DPPH and ABTS radical scavenging abilities of > 90%. C. mollissima extracts showed high UV-A and UV-B absorption efficiency. In addition, screening of the leaf extract demonstrated C. mollissima leaves as a rich source of tyrosinase inhibitors with maximum inhibitory activity and IC50 values of 96% and 336.43 μg/mL, respectively. This is the first-ever report of screening of leaf extract for its potential activieties. Eighteen phyto-compounds were identified from the C. mollissima leaf extract using gas chromatography-mass spectrometry and high-performance liquid chromatography techniques. Of these, the content of compounds 10, 11, 12, 13, 14 and 16 in the C. mollissima leaf extract was significantly high (14.35-88.42 μg/g). The molecular docking, ADMET and Lipinski’s rule of five analyses indicated high interaction efficacy of all the major compounds (DS values of -6.75 to -8.89 kcal/mol) with the target enzyme tyrosinase, had drug properties, and were non-toxic for human use.
關聯:	Chemistry & Biodiversity
DOI:	10.1002/cbdv.202500994
顯示於類別:	[化學學系暨研究所] 期刊論文

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