Taiwan’s National Health Insurance (NHI) system only utilizes 6-7% of the nation's GDP, yet it provides high healthcare quality and highly affordable services. However, healthcare staff are under considerable pressure, further exacerbating the strained workforce. This study applies six machine learning algorithms to explore important risk factors related to the excessive workload (overload) of healthcare institution staff, highlighting the significance of understanding these factors. Workload overload refers to the physiological state caused by long-term high stress, a serious 21st-century health issue. In Taiwan, the standard for recognizing overwork is based on workload during the six months and before the onset of illness, as outlined by the "Guidelines for Preventing Diseases Triggered by Abnormal Workload" from the Occupational Safety and Health Administration (OSHA) of the Ministry of Labor, Taiwan. These guidelines serve as a reference for defining working hours and overwork for both employers and employees. The Ministry of Labor mandates annual health checkups for workers across various industries in Taiwan, which includes an assessment of employee overload using the "Employee Overwork Assessment Scale.".