Effects of intubation and hypoxemia on intraventricular hemorrhage in preterm infants during the first week: An observational study

doi:10.1016/j.hrtlng.2024.09.013

淡江大學機構典藏 > 商管學院 > 企業管理學系暨研究所 > 期刊論文 > Item 987654321/126895

Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/126895

Title:	Effects of intubation and hypoxemia on intraventricular hemorrhage in preterm infants during the first week: An observational study
Authors:	Yu-Ting Chen, Hsiang-Ping Wu, Hsiang-Yun Lan, Hsueh-Fang Peng, Shyi-Jou Chen, Ti Yin, Jen-Jiuan Liaw, Yue-Cune Chang
Keywords:	Hypoxemia;Intensive care;Intraventricular hemorrhage;Intubation;Preterm infants
Date:	2024-10-04
Issue Date:	2025-03-20 09:29:28 (UTC+8)
Publisher:	Elsevier Inc.
Abstract:	Background: Preterm infants with intraventricular hemorrhage (IVH) are at a risk of developing neurodevelopmental disabilities. Few studies have examined the effects of oxygen saturation (SpO2) changes and intubation procedures on the risk of IVH. Objectives: We examined the effects of intubation and the rates of three thresholds of hypoxemia on the occurrence of IVH in preterm infants during their first week in the neonatal intensive care unit (NICU). Methods: In this prospective observational cohort study, preterm infants with a gestational age (GA) of <37 weeks were included from two Level III NICUs in Taiwan. Continuous electrocardiography was used to monitor SpO2 changes, and cranial ultrasonography was used to monitor IVH. Thresholds of hypoxemia (SpO2 levels of <80 %, <85 %, and <90 %) were screened by digitally sampling data at 10-s intervals. Generalized estimating equations were used with logistic regression to analyze the effects of intubation and the rates of the three thresholds of hypoxemia on the risk of IVH during the first week after birth. Results: In all preterm infants (N = 73), the mean GA was 31.55 weeks, and the mean birth weight was 1508.86 g. Intubation within 3 days of birth, duration of mechanical ventilation and oxygen use, hypoxemia rate, and maternal use of magnesium sulfate before and during delivery were significantly associated with IVH. A multivariate analysis revealed that intubation was a key factor associated with the occurrence of IVH across different thresholds of hypoxemia (p = 0.004). Conclusions: Although the rate of hypoxemia, duration of mechanical ventilation and oxygen use, and maternal use of magnesium sulfate were significantly associated with IVH, intubation within 3 days of birth was the key factor responsible for increased IVH risk.
Relation:	Heart & Lung 69, p.78-86
DOI:	10.1016/j.hrtlng.2024.09.013
Appears in Collections:	[企業管理學系暨研究所] 期刊論文

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