淡江大學機構典藏:Item 987654321/126592
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    題名: Flavonol-ruthenium complexes as antioxidant and anticancer agents
    作者: Wu, Ting-wei;Tang, Mei-hsin;Hsu, Pei-hsuan;Wu, Hsin-ying;Shih, Tzenge-lien
    關鍵詞: Anti-inflammatory;Anticancer;Antioxidant;Flavonol;Flavonol-ruthenium complexes
    日期: 2024-09-11
    上傳時間: 2024-12-18 12:05:29 (UTC+8)
    摘要: Flavonol-metal complexes can enhance the biological activity of flavonols. Inspired by the potential of ruthenium-based drugs in pharmaceutical applications, seven flavonol-Ru (II) complexes were synthesized to evaluate their biological activities. Among these compounds, compounds 8, 11, and 12 showed potent antioxidant activities. Compound 12 exhibited superior anti-inflammatory activity to natural quercetin, which served as a positive control. This study is the first to report the free radical scavenging abilities and antioxidant activity of flavonol-Ru (II) complexes. Furthermore, compound 12 demonstrated comparable efficacy to 5-FU against human non-small-cell lung cancer cells (A549). These results strongly support the potential of flavonol-Ru (II) agents.
    關聯: ChemMedChem 19(24),　e202400313
    DOI: 10.1002/cmdc.202400313
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