淡江大學機構典藏:Item 987654321/125709
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    题名: Effects of bradycardia, hypoxemia and early intubation on bronchopulmonary dysplasia in very preterm infants: An observational study
    作者: Yu-Ting Chen;Hsiang-Yun Lan;Yu-Lun Tsai;Hsiang-Ping Wu;Jen-Jiuan Liaw;Yue-Cune Chang
    关键词: Hypoxemia;Early intubation;Intensive care;Bronchopulmonary dysplasia;Preterm infants
    日期: 2024-03-11
    上传时间: 2024-07-31 12:09:40 (UTC+8)
    出版者: Elsevier Inc.
    摘要: Background
    Bronchopulmonary dysplasia (BPD) is the most common pulmonary complication in preterm infants.

    Objectives
    The study aimed to explore the effects of bradycardia, hypoxemia, and early intubation on BPD in very preterm infants.

    Methods
    This is a prospective observational cohort study. Preterm infants with a mean gestational age of 28.67 weeks were recruited from two level III neonatal intensive care units (NICUs) in Taiwan. Continuous electrocardiography was used to monitor heart rates and oxygen saturation (SpO2). Infants were monitored for heart rates of <100 beats per minute and SpO2 levels of <90 % lasting for 30 s. Generalized estimating equations were used to analyze the effects of bradycardia, hypoxemia, and early intubation on BPD in very preterm infants. Model fit was visually assessed using receiver operating characteristic curve analysis.

    Results
    Bradycardia, hypoxemia, and early intubation significantly increased the odds of BPD among the preterm infants (N = 39) during NICU stay; the odds ratios for bradycardia, hypoxemia, and early intubation for BPD versus non-BPD were 1.058, 1.013, and 29.631, respectively (all p < 0.05). A model combining bradycardia, hypoxemia, and early intubation accurately predicted BPD development (area under the curve = 0.919).

    Conclusions
    Bradycardia, hypoxemia, and early intubation significantly increased the odds of BPD among very preterm infants during NICU stay. The model combining bradycardia, hypoxemia, and early intubation accurately predicted BPD development.
    關聯: Heart & Lung 65,　p.109-115
    DOI: 10.1016/j.hrtlng.2024.02.009
    显示于类别:[企業管理學系暨研究所] 期刊論文

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