Effects of bradycardia, hypoxemia and early intubation on bronchopulmonary dysplasia in very preterm infants: An observational study

doi:10.1016/j.hrtlng.2024.02.009

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題名:	Effects of bradycardia, hypoxemia and early intubation on bronchopulmonary dysplasia in very preterm infants: An observational study
作者:	Yu-Ting Chen;Hsiang-Yun Lan;Yu-Lun Tsai;Hsiang-Ping Wu;Jen-Jiuan Liaw;Yue-Cune Chang
關鍵詞:	Hypoxemia;Early intubation;Intensive care;Bronchopulmonary dysplasia;Preterm infants
日期:	2024-03-11
上傳時間:	2024-07-31 12:09:40 (UTC+8)
出版者:	Elsevier Inc.
摘要:	Background Bronchopulmonary dysplasia (BPD) is the most common pulmonary complication in preterm infants. Objectives The study aimed to explore the effects of bradycardia, hypoxemia, and early intubation on BPD in very preterm infants. Methods This is a prospective observational cohort study. Preterm infants with a mean gestational age of 28.67 weeks were recruited from two level III neonatal intensive care units (NICUs) in Taiwan. Continuous electrocardiography was used to monitor heart rates and oxygen saturation (SpO2). Infants were monitored for heart rates of <100 beats per minute and SpO2 levels of <90 % lasting for 30 s. Generalized estimating equations were used to analyze the effects of bradycardia, hypoxemia, and early intubation on BPD in very preterm infants. Model fit was visually assessed using receiver operating characteristic curve analysis. Results Bradycardia, hypoxemia, and early intubation significantly increased the odds of BPD among the preterm infants (N = 39) during NICU stay; the odds ratios for bradycardia, hypoxemia, and early intubation for BPD versus non-BPD were 1.058, 1.013, and 29.631, respectively (all p < 0.05). A model combining bradycardia, hypoxemia, and early intubation accurately predicted BPD development (area under the curve = 0.919). Conclusions Bradycardia, hypoxemia, and early intubation significantly increased the odds of BPD among very preterm infants during NICU stay. The model combining bradycardia, hypoxemia, and early intubation accurately predicted BPD development.
關聯:	Heart & Lung 65,　p.109-115
DOI:	10.1016/j.hrtlng.2024.02.009
顯示於類別:	[企業管理學系暨研究所] 期刊論文

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