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https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/125639
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| 题名: | The angiogenesis-modulating effects of coumarin-derivatives |
| 作者: | Huang, Han-ting;Huang, Ching-yuan;Lee, Chih-jou;Sun, Bo-jie;Wen, Chi-chung;Wang, Yun-hsin;Chen, Yau-hung |
| 日期: | 2024-02-19 |
| 上传时间: | 2024-07-31 12:05:55 (UTC+8) |
| 摘要: | Coumarin is a natural compound that is rich in plants. Coumarin and its derivates were reported to have many biological activities, such as anti-bacterial, anti-tumor, and anti-coagulation. In this study, we examined the angiogenic modulating activities of six previously synthesized coumarin derivatives (Compound #1-#6) in zebrafish embryos and further confirmed them in a chick model. According to the survival rate in a zebrafish model, Compound #1 (100 %), #2 (82.5–100 %), and #4 (100 %) showed much less toxicity than Compound #3 (19.2–100 %), #5 (0–100 %), and #6 (0–100 %). Using a green blood vessel fluorescent transgenic fish Tg(fli1:egfp) to record the angiogenesis-modulating effects of Compound #1, #2, and #4, we found that Compound #2 had the highest effects in interfering intersegmental vessel growth, subintestinal vein growth, and caudal vein plexus remodeling. Chick chorioallantoic membrane (CAM) assay also showed that Compound #2 exposure led to a reduction of blood vessel growth. Real-time PCR experiments revealed that Compound #2 significantly changed the expression of vascular growth-related genes flt1, cdh5, and nrp1a in zebrafish. Based on our data from zebrafish and chick models, a new coumarin-derivative (Compound #2) possesses anti-angiogenic activity with low toxicity, but further investigation in mammal models is asked to confirm our findings. |
| 關聯: | Comparative Biochemistry and Physiology Part C 278, 109862 |
| DOI: | 10.1016/j.cbpc.2024.109862 |
| 显示于类别: | [應用數學與數據科學學系] 期刊論文
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