Palladium-catalyzed cascade endo-dig cycloisomerization and olefination with alkenes to access fused oxatricyclic compounds

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Title:	Palladium-catalyzed cascade endo-dig cycloisomerization and olefination with alkenes to access fused oxatricyclic compounds
Authors:	Yi-En Liang, Ming-Yiang Chang, Hsi Ho, Chun-Tang Chiou, Balaji D. Barve, Wen-Tai Li
Keywords:	Addition reactions,Catalysts,Cyclization,Hydrocarbons,Palladium
Date:	2023-11
Issue Date:	2024-07-23 12:06:11 (UTC+8)
Publisher:	American Chemical Society
Abstract:	A novel cascade Pd(II)-catalyzed endo-dig cycloisomerization and olefination reaction of 2-benzyl-3-alkynyl chromones with activated/unactivated alkenes has been developed for the synthesis of fused oxatricyclic compounds. This concise one-pot synthetic approach was applied to the difunctionalization of unbiased alkynes based on 2-benzyl-3-(alkynyl)-4H-chromen-4-one via O-attack endo-dig cycloisomerization, followed by olefination with both activated and unactivated alkenes.
Relation:	Organic Letters 25(46), pp.8194–8198
DOI:	10.1021/acs.orglett.3c02896
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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