| 題名: | Palladium-catalyzed cascade endo-dig cycloisomerization and olefination with alkenes to access fused oxatricyclic compounds |
| 作者: | Yi-En Liang, Ming-Yiang Chang, Hsi Ho, Chun-Tang Chiou, Balaji D. Barve, Wen-Tai Li |
| 關鍵詞: | Addition reactions,Catalysts,Cyclization,Hydrocarbons,Palladium |
| 日期: | 2023-11 |
| 上傳時間: | 2024-07-23 12:06:11 (UTC+8) |
| 出版者: | American Chemical Society |
| 摘要: | A novel cascade Pd(II)-catalyzed endo-dig cycloisomerization and olefination reaction of 2-benzyl-3-alkynyl chromones with activated/unactivated alkenes has been developed for the synthesis of fused oxatricyclic compounds. This concise one-pot synthetic approach was applied to the difunctionalization of unbiased alkynes based on 2-benzyl-3-(alkynyl)-4H-chromen-4-one via O-attack endo-dig cycloisomerization, followed by olefination with both activated and unactivated alkenes. |
| 關聯: | Organic Letters 25(46), pp.8194–8198 |
| DOI: | 10.1021/acs.orglett.3c02896 |
| 顯示於類別: | [化學學系暨研究所] 期刊論文
|