Assessment of the chemical profile and potential medical effect of flavonoids-rich extract of Eclipta prostrata L. collected in the Central Highland of Vietnam

doi:10.3390/ph16101476

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/125499

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题名:	Assessment of the chemical profile and potential medical effect of flavonoids-rich extract of Eclipta prostrata L. collected in the Central Highland of Vietnam
作者:	Phan TKP, Wang SL, Nguyen QV, Phan TQ, Nguyen TT, Toan TTT, Nguyen AD, Nguyen VB, Doan MD
日期:	2023-10-16
上传时间:	2024-07-05 12:05:29 (UTC+8)
出版者:	MDPI
摘要:	Eclipta prostrata L. (EPL), a medicinal plant, is widely utilized in the central highlands of Vietnam. This study aims to assess the chemical profile and potential medical effects of an EPL extract rich in flavonoids. A total of 36 secondary metabolites were identified from the EPL extract through GC-MS and UHPLC-UV analysis. Among them, 15 volatile compounds and several phenolic and flavonoid chemicals, including salicylic acid, epicatechin gallate, isovitexin, and apigetrin, were reported in EPL extract for the first time. This herbal extract demonstrated moderate inhibition against α-amylase and α-glucosidase, and high anti-oxidant and anti-acetylcholinesterase activities (IC50 = 76.8 ± 0.8 μg/mL). These promising attributes can be likely attributed to the high levels of major compounds, including wedelolactone (1), chlorogenic acid (3), epicatechin gallate (6), salicylic acid (8), isovitexin (9), apigetrin (11), and myricetin (12). These findings align with the traditional use of EPL for enhancing memory and cognitive function, as well as its potential benefits in diabetes management. The results of the molecular docking study reveal that the major identified compounds (1, 6, 9, and 11) showed a more effective acetylcholinesterase inhibitory effect than berberine chloride, with good binding energy (DS values, −12.3 to −14.3 kcal/mol) and acceptable values of RMSD (1.02–1.67 Å). Additionally, almost all the identified major compounds exhibited good ADMET properties within the required limits.
關聯:	Pharmaceuticals 16(10), 1476
DOI:	10.3390/ph16101476
显示于类别:	[化學學系暨研究所] 期刊論文

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