淡江大學機構典藏:Item 987654321/125462
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    题名: Baicalein suppresses HER2-mediated malignant transformation of HER2-overexpressing ovarian cancer cells by downregulating HER2 gene expression.
    作者: Chuang TC*, Fang GS, Hsu SC, Lee YJ, Shao WS, Wang V., Lee SL, Kao MC, Ou CC.
    关键词: EGFR family;HER2;baicalein;malignant transformation;ovarian cancer.
    日期: 2023-07
    上传时间: 2024-04-01 12:05:16 (UTC+8)
    出版者: John Wiley & Sons, Inc.
    摘要: The upregulation of the HER2 oncogene is associated with a variety of human cancers and is associated with poor prognosis. Baicalein is reported to have anti-tumor activity, but the molecular mechanism of this effect in HER2-positive cancer cells has not been studied. In this study, our data showed that baicalein can inhibit the proliferation and transformation potential of ovarian cancer cells overexpressing HER2. Baicalein treatment caused a dose-dependent inhibition of HER2 gene expression at the transcriptional level. Baicalein acted on ovarian cancer cells overexpressing HER2 to downregulate the PI3K/Akt signaling pathway downstream of HER2 and inhibit the expression or activity of downstream targets, such as VEGF and cyclin D1 and MMP2. Oral administration of baicalein supplemented with a pharmaceutical excipient significantly inhibited the growth of HER2-overexpressing ovarian SKOV-3 cancer xenografts in mice. These results suggest that downregulation of HER2 gene expression by baicalein at the transcriptional level contributes to inhibit the in vitro and in vivo proliferation and HER2-mediated malignant transformation of HER2-overexpressing ovarian cancer cells.
    關聯: Environmental Toxicology 38(7), p.1609-1617
    DOI: 10.1002/tox.23790
    显示于类别:[化學學系暨研究所] 期刊論文

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