Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging

doi:10.1021/acsanm.3c03626

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/124696

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题名:	Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging
作者:	Huang, Chia-chi
关键词:	carbon nanodots (CDs),bactericidal,bacteriostatic,Escherichia coli O157:H7,Salmonella enterica,Staphylococcus aureus
日期:	2023-10-13
上传时间:	2023-11-01 12:05:16 (UTC+8)
摘要:	Carbon nanodots (CDs) are known to inhibit the growth of bacteria, and a developing trend is observed in the literature that attributes such activities specifically to photoactivation, N-doping, and/or surface charge. In this study, we demonstrate that CDs can inhibit bacteria growth as well without these predispositions. Using the minimum inhibitory concentration and minimum bactericidal concentration protocols, we study, without irradiation, the inhibitory activities of CDs that are low in N-content and surface charge, against Escherichia coli O157:H7, Salmonella enterica ser. Typhimurium, and Staphylococcus aureus. The CDs are further tested in a zebrafish model for acute toxicity. These CDs exhibit antibacterial activities comparable to those of previously reported CDs with IC50s of 0.66, 0.75, and 1.00 mg/mL for the three bacteria, respectively. They are also shown to have manageable acute toxicity for safe applications in areas such as antibacterial wound dressing and food packaging. These results indicate that our knowledge base of the required characteristics for CDs to be antibacterial is incomprehensive despite the burgeoning of studies in this area, and the biological pathways leading to such activities are much more diverse than the current literature has suggested.
關聯:	ACS Appl. Nano Mater. 2023(6),　19200-19209
DOI:	10.1021/acsanm.3c03626
显示于类别:	[化學學系暨研究所] 期刊論文

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