Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents

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Title:	Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents
Authors:	Shih, Tzenge-lien
Keywords:	1,2,3-triazole;benzenesulfonamide;click chemistry;flavonol;human non-small-cell lung cancer cells;hybrid molecules
Date:	2023-08-04
Issue Date:	2023-10-23 12:05:45 (UTC+8)
Abstract:	Background The design and synthesis of hybrid molecules will explore finding new drugs. Objectives The synthesized hybrid molecules to evaluate their biological properties. Methods Apply click chemistry to tether flavonols and benzenesulfonamide. Results Two drug candidates show potential against lung cancer. Conclusions Two drug candidates did not affect the normal cells and provided a new drug design route.
Relation:	Journal of the Chinese Chemical Society 70(10),　p.1924-1936
DOI:	10.1002/jccs.202300279
Appears in Collections:	[Doctoral Program in Applied Science] Journal Article

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