淡江大學機構典藏:Item 987654321/124324
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    题名: Protection-Free Strategy for the Synthesis of Boro-Depsipeptides in Aqueous Media under Microwave-Assisted Conditions
    作者: Pan, Po-shen
    关键词: depsipeptide(s);α-acyloxyamide;passerini;multicomponent;microwave-assisted;DAHMI;boronic acid
    日期: 2022-04-04
    上传时间: 2023-08-02 12:05:13 (UTC+8)
    摘要: In this report, 19 boron-containing depsipeptides were synthesized via microwave-assisted Passerini three-component reaction (P-3CR) in an aqueous environment. The linker-free DAHMI fluorescent tagging approach was used on selected boron-containing compounds to study the relationship between their structures and their level of cellular uptake of HEK293 cells. The biological data retrieved from the DAHMI experiments indicated that while the structures of tested compounds may be highly similar, their bio-distribution profile could be vastly distinctive. The reported optimized one-pot synthetic strategy along the linker-free in vitro testing protocol could provide an efficient platform to accelerate the development of boron-containing drugs.
    關聯: Molecules 2022 27(7), 2325
    DOI: 10.3390/molecules27072325
    显示于类别:[化學學系暨研究所] 期刊論文

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