Organoboron compounds are widely used in catalytic reactions, medicinal chemistry, chemosensors, and polymer applications, because of their low toxicity, high stability, Lewis acidity, chemical versatility, and ability to form covalent bonds with their nucleophilic targets, In this report, we demonstrate how to efficiently assemble tetra boronate-containing compounds at the gram-scale via a one-pot modified microwave-assisted Ugi-4CR reaction. These boronate esters can then be transformed into the corresponding boronic acids under a reliable deprotection method, also reported herein.
Relation:
European Journal of Organic Chemistry 2022(31), e202200379
