Bioconversion of peanut oil processing by-product into hemi-pyocyanin and its novel anti-α-glucosidase effect

doi:10.3390/pr11051468

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/124109

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題名:	Bioconversion of peanut oil processing by-product into hemi-pyocyanin and its novel anti-α-glucosidase effect
作者:	Nguyen, Van Bon;Wang, San-Lang;Nguyen, Anh Dzung
關鍵詞:	diabetes;α-glucosidase inhibitors;hemi-pyocyanin;organic industrial waste;peanut oil processing by-product;fermentation;bioreactor systems
日期:	2023-05-12
上傳時間:	2023-05-16 12:05:15 (UTC+8)
出版者:	MDPI
摘要:	Hemi-pyocyanin (HPC) is a heterocyclic nitrogenous compound with some reported potential medical effects. The current report aimed to investigate the potential use of organic industrial waste for the production of HPC via microbial fermentation. The novel antidiabetic activity of HPC was also accessed and reported in this work. A peanut oil processing by-product (groundnut cake) was screened as the best substrate for Pseudomonas aeruginosa TUN03 conversion to obtain high-yield HPC. This compound was further produced in a 14 L bioreactor system on a large scale (6 L per pilot) and reached higher productivity (35.1 μg/mL) in a shorter time course of cultivation (8 h) compared to fermentation on a small scale in flasks (19.5 μg/mL; 3 days of fermentation). On assessing its activity, HPC demonstrated potent inhibition against α-glucosidase, an antidiabetic enzyme, with a low IC50 value (0.572 mg/mL) and a maximum inhibition rate of 100%. In an in silico study, HPC was found to inhibit α-glucosidase with a good binding energy score (−9.0 kcal/mol) via interaction with amino acids Lys156, Leu313, and Arg315 at the active site, and three bonds (1 H-acceptor and 2 pi-H) were generated. The data from five Lipkin’s rules and ADMET-based pharmacokinetics and pharmacology revealed that HPC possesses drug-like properties and good ADMET properties within the required allotted limitations. The data obtained in the current work highlighted the potential application of groundnut cakes for the eco-friendly and scaled-up production of HPC, a new anti-α-glucosidase agent that should be further investigated for type 2 diabetes management.
關聯:	Processes 2023 11(5), 1468
DOI:	10.3390/pr11051468
顯示於類別:	[化學學系暨研究所] 期刊論文

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