Molybdenum trioxide hybridized kaempferol: double-powered nanosystem for salvaging oxidative stress and electrochemical immunoprobing of interleukin-6

doi:10.1016/j.mtchem.2022.100809

機構典藏 > College of Engineering > Graduate Institute & Department of Electrical Engineering > Journal Article > Item 987654321/124078

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/124078

题名:	Molybdenum trioxide hybridized kaempferol: double-powered nanosystem for salvaging oxidative stress and electrochemical immunoprobing of interleukin-6
作者:	G. R. Pandey;P. Kanagavalli;K. Karnam;K. T. Arul;P. Monisha;C. L. Dong;J. L. Chen;M. Veerapandian;J. Nirmal
日期:	2022-06
上传时间:	2023-05-12 12:08:47 (UTC+8)
出版者:	Elsevier Ltd
摘要:	Intracellular reactive oxygen species (iROS) are the culprit in inflammation-linked diseases. Excessive radical generation triggers an inflammation cascade involving interleukin-6 (IL-6) and other cytokines release, causing oxidative stress to cells. Developing healthcare materials with dual-functionality controlling iROS and diagnosing IL-6 would be extremely beneficial for chronic inflammatory disease management. Herein, molybdenum trioxide hybridized kaempferol nanoparticles (MoHK NPs) have been synthesized with iROS scavenging and in situ electrochemical redox property for immunoassay of IL-6. Physicochemical integrity of nanosystem comprising MoHK NPs is characterized by X-ray absorption/photoelectron, Raman, and fourier transform infrared (FT-IR) spectroscopy as well as scanning transmission electron microscopy–high-angle annular dark field microscopic analysis. In vitro radical scavenging mechanism of MoHK NPs was studied by electron paramagnetic spectroscopy. Distinctly, these MoHK NPs exhibit a clinically significant antioxidant function and cytocompatibility with RAW 264.7 macrophage cell line. Bioaffinity layer–assisted monoclonal antibodies of IL-6 immobilized on MoHK electrode enable superior selectivity, electrochemical signal transduction (sensitivity 0.63 μA/fM/cm2), and rapid analytical response time even at ultralow IL-6 concentrations (detection limit 0.91 fM). This work demonstrates that hybridizing redox-active and antioxidant-rich phytochemical on metal oxide nanosystem can be a promising strategy for multifunctional theranostics.
關聯:	Materials Today Chemistry 24, 100809
DOI:	10.1016/j.mtchem.2022.100809
显示于类别:	[Graduate Institute & Department of Electrical Engineering] Journal Article

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	90	检视/开启

在機構典藏中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....