Attomolar analyte sensing technique for detection of Pb2+ and Hg2+ ions based on liquid crystal

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Title:	Attomolar analyte sensing technique for detection of Pb2+ and Hg2+ ions based on liquid crystal
Authors:	Asma Verdian;Zahra Khoshbin;Chih-Hsin Chen;Qiongzheng Hu
Keywords:	Heavy metal;Liquid crystal;Attosensor;Aptamer;Fish analysis
Date:	2022-10-27
Issue Date:	2023-04-28 17:58:27 (UTC+8)
Publisher:	Elsevier
Abstract:	Detecting the ultra-low abundance of heavy metals in real samples remains challenging and it requires the development of high-performance biosensing modalities. This work describes a novel strategy for design an ultra-sensitive liquid crystal (LC) aptasensor, in which the LCs reorientation induced by conformational changes of a triple helix molecular switch (THMS) structure is utilized for the quantitative detection of Pb2+ and Hg2+ ions. The developed aptasensor exhibits a wide linear range with the ultralow detection limits as low as 0.021 aM and 0.068 aM for Pb2+ and Hg2+, respectively. Besides, the results show that other analytes cause no interference. Noteworthy, this sensing strategy is easy to expand for other targets by altering the aptamer sequence without change of the triple-helix structure and can be used for multiple analyte detection. The developed aptasensor is promising powerful platform as a LC AttoSens for precision screening of hazardous residues in food analysis.
Relation:	Talanta 253, 124042
DOI:	10.1016/j.talanta.2022.124042
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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