A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges

doi:10.1186/s12951-022-01515-5

機構典藏 > College of Sciences > Graduate Institute & Department of Chemistry > Journal Article > Item 987654321/123403

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Title:	A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Authors:	Yang, L.-X.;Liu, Y.-C.;Cho, C.-H.;Chen, Y.-R.;Yang, C.-S.;Lu, Y.-L.;Zhang, Z.;Tsai, Y.-T.;Chin, Y.-C.;Yu, J.;Pan, H.-M.;Jiang, W.-R.;Chia, Z.-C.;Huang, W.-S.;Chiu, Y.-L.;Sun, C.-K.;Huang, Y.-T.;Chen, L.-M.;Wong, K.-T.;Huang, H.-M.;Chen, C.-H.;Chang, Y. J.;Huang, C.-C.;Liu, T.-M.
Keywords:	Polymer;Near-infrared red;Optoelectronic material;Photodynamic therapy;Theranostic;Multiphoton microscopy;Fluorescence imaging
Date:	2022-07-06
Issue Date:	2023-04-28 17:58:25 (UTC+8)
Publisher:	BMC
Abstract:	The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.
Relation:	Journal of Nanobiotechnology 20, 311
DOI:	10.1186/s12951-022-01515-5
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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