淡江大學機構典藏:Item 987654321/123298
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    Title: Progression of precancerous lesions to oral cancer: results based on the Taiwan National Health Insurance Database
    Other Titles: English
    Authors: Ie-BinLian;Yao-TingTseng;Che-ChunSu;Kuo-YangTsai
    Keywords: Premalignant lesions;Oral submucous fibrosis;Oral leukoplakia;Epidemiology
    Date: 2013-05
    Issue Date: 2023-04-28 17:33:50 (UTC+8)
    Publisher: Elsevier Ltd
    Abstract: Background
    Oral cancer (OC) is the leading cause of death from cancer in men between the ages of 25 and 44 in Taiwan. The survival rate for the last stage of OC is <20% while that for the earliest stage is >75%, which suggests the importance of the diagnosis of oral precancerous lesions (OPLs) in reducing OC mortality. The aim of this study was to analyze the time to OC event after OPL diagnosis, and to suggest the surveillance period necessary according to OPL type.

    Materials and methods
    This was a retrospective cohort study based on 1.0 million people randomly selected from the Taiwan National Health Insurance Database, which provided data on 3058 adult male patients aged ⩾20 years who were diagnosed with OPL for the first time between 1996 and 2009. The patient population was divided into two groups according to the type of lesion: oral submucous fibrosis (OSF) or oral leukoplakia (OLE). Age-standardized incidence rate (ASIR) and hazards rate (HR) were then estimated.

    Results
    The ASIR for OPL showed an increasing trend over the study period, the main contributor to this being OSF. The OSF group demonstrated a higher OC incidence rate than the OLE group.

    Conclusion
    Patients with both OLE and OSF carry a higher risk for OC than those with either OLE or OSF alone, and they may also experience malignant transformation at an earlier date (mostly within 5 years). The 5- and 10-year OC rate for both OLE and OSF was found to be 5% and around 10%, respectively. However, 10 years after the diagnosis of OPL, OSF carries a higher risk of developing into OC than OLE.
    Relation: Oral Oncology 49(5), p.427-430
    DOI: 10.1016/j.oraloncology.2012.12.004
    Appears in Collections:[Graduate Institute & Department of Statistics] Journal Article

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