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    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/123204

    題名: Synthesis of selenophene‐based chalcone analogs and assessment of their biological activity as anticancer agents
    作者: Shih, Tzenge-lien
    日期: 2023-04-05
    上傳時間: 2023-04-28 17:14:36 (UTC+8)
    摘要: Selenium is an essential micronutrient that is beneficial to human health. Selenium-containing drugs have been developed as antioxidants, anti-inflammatory, and anticancer agents. However, the synthesis of selenium-containing chalcones has not been fully explored. Therefore, we report the synthesis of novel selenophene-based chalcone analogs and reveal their biological activities as anticancer agents. Among the seven synthesized molecules, compounds 6, 8, and 10 exhibited anticancer activity with IC50 values of 19.98 ± 3.38, 38.23 ± 3.30, and 46.95 ± 5.68 μM, respectively, against human colorectal adenocarcinoma (HT-29) cells. Clonogenic assays and Western blot analysis tests further confirmed that compound 6 effectively induced apoptosis in HT-29 cells through mitochondrial- and caspase-3-dependent pathways.
    關聯: Archiv der Pharmazie 356(4)
    DOI: 10.1002/ardp.202200486
    顯示於類別:[應用科學博士班] 期刊論文


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