Differences in health‐related quality of life between European and Asian patients with hepatocellular carcinoma

doi:10.1111/ajco.12464

淡江大學機構典藏 > 理學院 > 應用數學與數據科學學系 > 期刊論文 > Item 987654321/122707

Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/122707

Title:	Differences in health‐related quality of life between European and Asian patients with hepatocellular carcinoma
Authors:	Chie, Wei‐chu;Blazeby, Jane M;Hsiao, Chin‐Fu;Chiu, Herng‐Chia;Poon, Ronnie T;Mikoshiba, Naoko;Al‐Kadhim, Gillian;Heaton, Nigel;Calara, Jozer;Collins, Peter;Caddick, Katharine;Costantini, Anna;Vilgrain, Valerie;Chiang, Chieh;Group, on behalf of the EORTC Quality of Life
Date:	2016-04
Issue Date:	2022-05-09 12:10:48 (UTC+8)
Abstract:	Aim The aim of this study is to explore the possible effects of clinical and cultural characteristics of hepatocellular carcinoma on patients’ health-related quality of life (HRQoL). Methods Patients with hepatocellular carcinoma from Asian and European countries completed the EORTC QLQ-C30 and the EORTC QLQ-HCC18. Comparisons were made using Student's t-test and Wilcoxon rank-sum test with method of false discovery to correct multiple comparisons. Multiway analysis of variance and model selection were used to assess the effects of clinical characteristics and geographic areas. Results Two hundred and twenty-seven patients with hepatocellular carcinoma completed questionnaires. After adjusting for demographic and clinical characteristics, Asian patients still had significantly better HRQoL scores in emotional functioning, insomnia, (QLQ-C30) and in sexual interest (QLQ-HCC18). We also found an interaction in physical functioning (QLQ-C30) and fatigue (QLQ-HCC18) between geographic region and marital status, married European had worse HRQoL scores than Asian singles. Conclusions Both clinical characteristics and geographic areas affected the HRQoL in with hepatocellular carcinoma. Cultural differences and clinical differences in the pattern of disease due to active surveillance of Asian countries may explain the results.
Relation:	Asia‐pacific Journal of Clinical Oncology 13(5), e304-e311
DOI:	10.1111/ajco.12464
Appears in Collections:	[應用數學與數據科學學系] 期刊論文

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