Synthesis of cinnamils and quinoxalines and their biological evaluation as anticancer agents

淡江大學機構典藏 > 理學院 > 應用科學博士班 > 期刊論文 > Item 987654321/122676

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题名:	Synthesis of cinnamils and quinoxalines and their biological evaluation as anticancer agents
作者:	Wang, Ruei‐Yu;Li, Cai‐Wei;Cho, Shu‐Tse;Chang, Chun‐Hao;Chen, Jih‐Jung;Shih, Tzenge‐Lien
关键词:	cinnamil;pancreatic cancer;quinoxaline
日期:	2022-05-02
上传时间:	2022-05-04 12:10:19 (UTC+8)
出版者:	Wiley-VCH Verlag GmbH & Co. KGaA
摘要:	We synthesized multiple cinnamils and quinoxalines to evaluate their anticancer activity. Cinnamils were used as precursors for quinoxalines via condensation with 1,2-diaminobenzene. Among the 26 synthesized compounds reported in this article, we found that cinnamil 3l exhibited its inhibitory effect with an IC50 value of 1.45 ± 0.98 μM, significantly higher than doxorubicin (8.5 ± 0.85 μM) against pancreatic cancer cells (PANC-1). Additionally, cinnamil 3l (IC50 10.98 ± 3.63 μM) showed less cytotoxicity than doxorubicin to Hs68 cells (0.92 ± 1.11 μM). The colony formation assay demonstrated that 3l obviously decreased the PANC-1 cell viability, and Western blot assays confirmed that 3l markedly induced apoptosis of PANC-1 cells through Bax, Bcl-2, and caspase 3 signaling cascades. These results demonstrate that cinnamil 3l has great potential to be further developed as a promising chemotherapeutic agent for pancreatic cancer.
關聯:	Archiv der Pharmazie 355(5), 2100448
DOI:	10.1002/ardp.202100448
显示于类别:	[應用科學博士班] 期刊論文

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