English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 60984/93521 (65%)
造访人次 : 1571162      在线人数 : 208
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/122352


    题名: Protective role of Bu-Zhong-Yi-Qi decoction on aristolochic acid-intoxicated zebrafish
    作者: JN, Tsai;YJ, Ding;KC, Lo;PH, Lu;CF, Chang;CC, Wen;BC, Wang;LL, Yang;YH, Chen
    关键词: Bu-Zhong-Yi-Qi Decoction;Zebrafish;Kidney;Aristolochic acid;Nephroprotection
    日期: 2022-01-17
    上传时间: 2022-03-04 12:11:37 (UTC+8)
    摘要: Purpose: To investigate the potential nephroprotective effects of a traditional Chinese medical prescription, Bu-Zhong-Yi-Qi Decoction (BZYQD) in an aristolochic acid (AA)-intoxicated zebrafish model.

    Methods: A green fluorescent zebrafish line Tg (wt1b:EGFP) was used, and different exposure protocols were applied. Once a suitable protective concentration of BZYQD was found, antibody staining and real-time PCR methods were applied and the pro-inflammatory gene expressions were determined.

    Results: The results showed that low dose (10 ppm) of BZYQD attenuates the AA-induced malformed kidney phenotype. This finding was further substantiated by an examination of the integrity of pronephric tubes in the treated embryos. Pre-treatment with BZYQD suppressed the elevated expressions of pro- inflammatory genes, including tumor necrosis factor-α and myeloperoxidase, induced by AA exposure (1.6 ~ 2.3-fold). This indicates that the nephroprotective effect of BZYQD may be mediated by suppression of pro-inflammatory gene expression. On the other hand, a high dose (500 ppm) of BZYQD caused nephrotoxic effect.

    Conclusion: An efficient model to identify AA-protective compounds using zebrafish embryos has been successfully established. Using this strategy, it has been found that BZYQD is nephroprotective in zebrafish embryos, and might have the potential to be applied in humans.
    關聯: Tropical Journal of Pharmaceutical Research 20(3), p.605-611
    DOI: 10.4314/tjpr.v20i3.24
    显示于类别:[數學學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML42检视/开启
    Protective role of Bu-Zhong-Yi-Qi decoction on aristolochic acid-intoxicated zebrafish.pdf632KbAdobe PDF17检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈