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    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/122343

    題名: Prognosis of Hypoglycemia Episode in Cirrhotic Patients during Hospitalization
    作者: Hung, Tsung-Hsing;Tseng, Chih-Wei;Tsai, Chih-Chun;Lee, Hsing-Feng
    關鍵詞: Hypoglycemia;Cirrhosis;Mortality
    日期: 2021-08-09
    上傳時間: 2022-03-04 12:11:19 (UTC+8)
    出版者: BioMed Central Ltd.
    摘要: Background
    Studies have shown that hyperglycemia in cirrhotic patients increases mortality. However, no population-based study has evaluated the influence of hypoglycemia upon hospital admission on death in these patients. The aim of this study was to assess the effect of hypoglycemia at admission on the mortality of patients with liver cirrhosis.

    The Taiwan National Health Insurance Database was searched, and 636 cirrhotic patients without baseline diabetes mellitus who presented with hypoglycemia upon hospitalized from 2010 to 2013 were included in the study. A one-to-four propensity score matching was performed to select a comparison group based on age, sex and comorbidities.

    The overall 30-day mortality rate was 30.2% in the hypoglycemia group and 7.4% in the non-hypoglycemia group (P < 0.001). After Cox regression modeling adjusting for age, sex and comorbid disorders, cirrhotic patients with hypoglycemia had a hazard ratio (HR) of 30-day mortality of 4.96 (95% confidence interval [CI] 4.05–6.08, P < 0.001) as compared to the non-hypoglycemia group. In subgroup analysis, the cirrhotic patients with hypoglycemia and hepatocellular carcinoma (HCC) had a 30-day mortality HR of 6.11 (95% confidence interval [CI] 4.40–8.49, P < 0.001) compared to those with neither hypoglycemia nor HCC.

    Hypoglycemia is a very important prognostic factor in the 30-day mortality of cirrhotic patients, especially in those with underlying HCC.

    Supplementary Information
    The online version contains supplementary material available at 10.1186/s12876-021-01895-2.
    關聯: BMC Gastroenterology 21, 319
    DOI: 10.1186%2Fs12876-021-01895-2
    顯示於類別:[數學學系暨研究所] 期刊論文


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