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https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/121673
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| 题名: | Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids |
| 作者: | Hung, Sung-Jen;Hong, Yi-An;Lin, Kai-Yu;Hua, Yi-Wen;Kuo, Chia-Jou;Hu, Anren;Shih, Tzenge-Lien;Chen, Hao-Ping |
| 关键词: | bisdemethoxycurcumin;curcumin;curcuminoid;demethoxycurcumin;photodynamic inactivation;Staphylococcus aureus;Staphylococcus epidermis |
| 日期: | 2020-11-27 |
| 上传时间: | 2021-12-16 12:10:59 (UTC+8) |
| 摘要: | In our previous study, we have demonstrated that curcumin can efficiently kill the anaerobic bacterium Propionibacterium acnes by irradiation with low-dose blue light. The curcuminoids present in natural plant turmeric mainly include curcumin, demethoxycurcumin, and bisdemethoxycurcumin. However, only curcumin is commercially available. Eighteen different curcumin analogs, including demethoxycurcumin and bisdemethoxycurcumin, were synthesized in this study. Their antibacterial activity against Gram-positive aerobic bacteria Staphylococcus aureus and Staphylococcus epidermidis was investigated using the photodynamic inactivation method. Among the three compounds in turmeric, curcumin activity is the weakest, and bisdemethoxycurcumin possesses the strongest activity. However, two synthetic compounds, (1E,6E)-1,7-bis(4-bromophenyl)hepta-1,6-diene-3,5-dione and (1E,6E)-1,7-bis(3-bromophenyl)hepta -1,6-diene-3,5-dione, possess the best antibacterial activity among all compounds examined in this study. Their chemical stability is also better than that of bisdemethoxycurcumin, and thus has potential for future clinical applications. |
| 關聯: | International Journal of Molecular Sciences 21(23), 9024 |
| DOI: | 10.3390/ijms21239024 |
| 显示于类别: | [應用科學博士班] 期刊論文
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