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    題名: Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery
    作者: Don, Trong-Ming;Chang, Wan-Ju;Jheng, Pei-Ru;Huang, Yi-Cheng;Chuang, Er-Yuan
    關鍵詞: Chitosan;Curcumin;Fucoidan;Intranasal to brain drug delivery;Multi-functional nanocarrier;Suppression of brain inflammatory
    日期: 2021-06-30
    上傳時間: 2021-10-14 12:11:34 (UTC+8)
    出版者: Elservier
    摘要: Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of free curcumin needs to be administered to achieve an effective level in the brain because of its poor water-solubility. Fucoidan and chitosan were reported to respectively target P-selectin and acidic microenvironment expressed by pathologically inflammatory cells/tissues. Herein, the self-assembly of chitosan and fucoidan which could encapsulate curcumin was developed to form the multi-stimuli-responsive nanocarriers, and their pathological pH- and P-selectin-responsive aspects were characterized. Through intranasal delivery to the brain, these curcumin-containing chitosan/fucoidan nanocarriers with dual pH-/P-selectin-targeting properties to the brain lesions improved drug delivery, distribution, and accumulation in the inflammatory brain lesions as evidenced by an augmented inhibitory effect against brain inflammation. This promising multifunctional nanocarrier with a novel drug-delivery route should allow potential clinical biomedical uses by neurosurgeon in the future.
    關聯: International Journal of Biological Macromolecules 181, p.835-846
    DOI: 10.1016/j.ijbiomac.2021.04.045
    顯示於類別:[化學工程與材料工程學系暨研究所] 期刊論文

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