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    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/121473

    題名: Crosslinked complex films based on chitosan and ulvan with antioxidant and whitening activities
    作者: Don, Trong-Ming;Liu, Li-Min;Chen, Michelle;Huang, Yi-Cheng
    日期: 2021-10
    上傳時間: 2021-10-14 12:11:32 (UTC+8)
    出版者: Elservier
    摘要: The aim of this study was to prepare complex films based on chitosan and ulvan through crosslinking and analyze their bioactivities. The ulvan extracted from Ulva lactuca was composed of uronic acid and sulfated rhamnose as the main monosaccharides in which it had a sulfate content of 16.25 ± 1.19 wt%. During preparation, ionic crosslinking occurred between chitosan and ulvan and enhanced by adding tripolyphosphate and glycerol, in which the tensile strength was increased from 1.09 to 2.67 MPa. Compared to chitosan-based film, the complex films had higher swelling ratio and water vapor transmission rate. The complex films showed antioxidant and whitening activities mainly due to the ulvan. A sustained ulvan release (40–65% for 12-h releasing) from these films was observed. Especially, addition of chlorophyll to films increased the ulvan release to 64.8% and enhanced their bioactivities, showing a synergism effect. They were biocompatible to normal cells but toxic to melanoma cancer cell, presenting cell selectivity which was related to the reactive oxygen species generation. Briefly, the crosslinked complex films based on chitosan and ulvan with suitable physicochemical properties and improved antioxidant and whitening ability could have a great potential to be used as a new biomaterial in the future.
    關聯: Algal Research 58, 102423
    DOI: 10.1016/j.algal.2021.102423
    顯示於類別:[化學工程與材料工程學系暨研究所] 期刊論文


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