淡江大學機構典藏:Item 987654321/121078
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    题名: Bioproduction of prodigiosin from fishery processing waste-shrimp head and evaluation of its potential bioactivities
    作者: VB, Nguyen;SL, Wang;AD, Nguyen;TQ, Phan;Techato, K;Pradit, S
    关键词: fish industry waste;shrimp exoskeleton;marine chitinous wastes;microbial technology;prodigiosin;antioxidants;anti-Alzheimer activity;docking study
    日期: 2021-08-11
    上传时间: 2021-08-25 12:15:47 (UTC+8)
    出版者: MDPI
    摘要: The aim of this work was to reuse a fish processing waste, shrimp head powder (SHP), for the production of prodigiosin (PG) via microbial technology and to assess its potential bioactivities. PG was produced in a 12 L-bioreactor system, and the highest PG productivity of 6310 mg L−1 was achieved when Serratia marcescens CC17 was used for fermentation in a novel designed medium (6.75 L) containing 1.5% C/N source (SHP/casein = 9/1), 0.02% K2SO4, ans 0.025% Ca3(PO4)2, with initial pH 7.0, and fermentation was performed at 28 °C for 8 h. The purified PG showed moderate antioxidants, efficient anti-NO (anti-nitric oxide), and acetylcholinesterase (AChE) inhibitory activities. In a docking study, PG showed better binding energy scores (−12.3 kcal/mol) and more interactions (6 linkages) with several prominent amino acids in the biding sites on AChE that were superior to those of Berberine chloride (−10.8 kcal/mol and one linkage). Notably, this is the first investigation using shrimp heads for the mass bioproduction of PG with high productivity, and Ca3(PO4)2 salt was also newly found to significantly enhance PG production by S. marcescens. This study also provided available data on the anti-NO and anti-AChE effects of PG, especially from the docking simulation PG towards AChE that was described for the first time in this study. The above results suggest that SHP is a good material for the cost-effective bioproduction of PG, which is a potential candidate for anti-NO and anti-Alzheimer drugs.
    關聯: Fishes,6(3),30
    DOI: 10.3390/fishes6030030
    显示于类别:[化學學系暨研究所] 期刊論文

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