Synthesis of N-Heterocycles via Transition-Metal-Catalyzed Tandem Addition/ Cyclization of a Nitrile

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/120974

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题名:	Synthesis of N-Heterocycles via Transition-Metal-Catalyzed Tandem Addition/ Cyclization of a Nitrile
作者:	Hsieh（謝仁傑）, Jen-Chieh;Su, Haw-Lih
关键词:	transition-metal-catalyzed;nitrile addition;cyclization;N-heterocycles;natural alkaloids
日期:	2020-01-09
上传时间:	2021-08-20 12:13:08 (UTC+8)
摘要:	The diverse methodologies to synthesize N-heterocycles through transition-metal-catalyzed cascade addition/cyclization of a nitrile are discussed in this review. Aspects relating to three types of transition-metal-catalyzed addition of a nitrile with subsequent cyclization include (1) a transition-metal acting as a Lewis acid to accelerate the nucleophilic addition of a nitrile, (2) the late-transition-metal-catalyzed 1,2-insertion of a nitrile, and (3) an in situ generated radical by transition-metal catalysis to implement a radical addition/cyclization tandem reaction. Applications for the synthesis of natural alkaloids, their derivatives, and some bioactive compounds are also summarized herein.
關聯:	Synthesis 52(6), p.819–833
DOI:	10.1055/s-0039-1691561
显示于类别:	[化學學系暨研究所] 期刊論文

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