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    題名: Bio-processing of marine chitinous wastes for the production of bioactive prodigiosin
    作者: TH, Nguyen;SL, Wang;DM, Nguyen;AD, Nguyen;TH, Nguyen;MD, Doan;VA, Ngo;CT, Doan;YH, Kuo;VB, Nguyen
    關鍵詞: prodigiosin;Serratia marcescens;shrimp shells;bioreactor;fermentation;antioxidants;anti‐NO activity
    日期: 2021-05-24
    上傳時間: 2021-06-10 12:12:31 (UTC+8)
    出版者: MDPI
    摘要: Recently, microbial prodigiosin (PG) has received much attention due to its numerous
    beneficial applications. The aim of this study was to establish the bioprocessing of marine chitinous
    wastes (MCWs) for the cost‐effective preparation of PG. Of the MCWs, demineralized shrimp shell
    powders (de‐SSP) were found to be a potential source of carbon/nitrogen (C/N) for PG production
    by bacterial fermentation using Serratia marcescens strains. Further, PG scale‐up production was in‐
    vestigated in a 15 L bioreactor system, and the highest yield (6200 mg/L) was achieved during fer‐
    mentation using 5 L of a novel‐designed culture broth that included 1.60% C/N sources (a de‐SSP/ca‐
    sein ratio of 7/3), 0.02% K2SO4, and 0.05% K2HPO4, with an initial pH of 6–7. Fermentation was con‐
    ducted in the dark at 27.5 °C for 8.0 h. This study was the first to report on the utilization of shrimp
    wastes for cost‐effective, large‐scale (5 L/pilot) PG production with high productivity (6200 mg/L)
    in a short cultivation time. The combination of 0.02% K2SO4 and 0.05% K2HPO4 was also found to
    be a novel salt composition that significantly enhanced PG yield. The red compound was purified
    and confirmed as PG after analyzing its HPLC profile, mass, and UV/vis spectra. The purified PG
    was then tested for its bioactivities and showed effective anticancer activities, moderated antioxi‐
    dant activities, and novel anti‐NO effects.
    關聯: Molecules 26 (11), 3138
    DOI: 10.3390/molecules26113138
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