Exploring the Effects of Pharmacological, Psychosocial, and Alternative/Complementary Interventions in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: Meta-Regression Approach

doi:10.1093/ijnp/pyab034

淡江大學機構典藏 > 理學院 > 數學學系暨研究所 > 期刊論文 > Item 987654321/120828

請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/120828

題名:	Exploring the Effects of Pharmacological, Psychosocial, and Alternative/Complementary Interventions in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: Meta-Regression Approach
作者:	Kung-Han Yang;Yue-Cune Chang;Ruu-Fen Tzang;Hsien-Yuan Lane
關鍵詞:	ADHD;treatment efficacy;pharmacotherapy;behavior therapy;meta-regression
日期:	2021-10-23
上傳時間:	2021-06-07 12:10:21 (UTC+8)
出版者:	Oxford University Press
摘要:	Background Till now, there have been various therapies for attention-deficit/hyperactivity disorder (ADHD), but the previous meta-analysis of ADHD efficacy remains unclear. This study aims to systemically meta-regress the effect sizes of psychostimulant pharmacotherapy (methylphenidate and lisdexamfetamine), non-stimulant pharmacotherapy (atomoxetine and alpha-2 agonists), psychosocial therapy (parental behavioral therapy [PBT]), combination therapy (psychostimulant plus PBT), and alternative/complementary interventions to determine the right treatment for ADHD. Methods We searched various ADHD interventions from the MEDLINE and PubMed databases (National Center for Biotechnology Information) between January 1, 1980 and July 30, 2018. Following the meta-analysis of random effects, the meta-regression analyses were used to explore factors potentially influencing treatment efficacy. The confounding variables included type of treatment, type of study, age, type of symptom scale used, and year of publication. Results A total of 107 trials (N = 9883 participants) were included. After adjustment, compared to the psychostimulant therapy (28 trial, 2134 participants), non-stimulant pharmacotherapy (28 trials, 4991 participants) and alternative/complement intervention (25 trials, 1195 participants) were less effective by the effect sizes (ES) of -0.384 (p = 0.004) and -0.419 (p = 0.028) respectively. However, compared to psychostimulant, PBT (19 trials, 1122 participants; ES = -0.308, p = 0.095) and combination of psychostimulant and PBT (7 trials, 441participants; ES = -0.196, p = 0.209) did not differ significantly. Conclusions Psychostimulant therapy surpassed non-stimulant pharmacotherapy and alternative/complement intervention. Psychostimulant therapy, PBT, and combination of psychostimulant therapy and PBT appear to be similar in efficacy according to this meta-regression.
關聯:	International Journal of Neuropsychopharmacology 24(10), p.776–786,
DOI:	10.1093/ijnp/pyab034
顯示於類別:	[數學學系暨研究所] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	233	檢視/開啟

在機構典藏中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....