English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 62805/95882 (66%)
造访人次 : 3917147      在线人数 : 652
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻

    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/120828

    题名: Exploring the Effects of Pharmacological, Psychosocial, and Alternative/Complementary Interventions in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: Meta-Regression Approach
    作者: Kung-Han Yang;Yue-Cune Chang;Ruu-Fen Tzang;Hsien-Yuan Lane
    关键词: ADHD;treatment efficacy;pharmacotherapy;behavior therapy;meta-regression
    日期: 2021-10-23
    上传时间: 2021-06-07 12:10:21 (UTC+8)
    出版者: Oxford University Press
    摘要: Background Till now, there have been various therapies for attention-deficit/hyperactivity disorder
    (ADHD), but the previous meta-analysis of ADHD efficacy remains unclear. This study aims to
    systemically meta-regress the effect sizes of psychostimulant pharmacotherapy (methylphenidate and
    lisdexamfetamine), non-stimulant pharmacotherapy (atomoxetine and alpha-2 agonists), psychosocial
    therapy (parental behavioral therapy [PBT]), combination therapy (psychostimulant plus PBT), and
    alternative/complementary interventions to determine the right treatment for ADHD. Methods We
    searched various ADHD interventions from the MEDLINE and PubMed databases (National Center
    for Biotechnology Information) between January 1, 1980 and July 30, 2018. Following the meta-analysis of random effects, the meta-regression analyses were used to explore factors potentially
    influencing treatment efficacy. The confounding variables included type of treatment, type of study,
    age, type of symptom scale used, and year of publication. Results A total of 107 trials (N = 9883
    participants) were included. After adjustment, compared to the psychostimulant therapy (28 trial,
    2134 participants), non-stimulant pharmacotherapy (28 trials, 4991 participants) and
    alternative/complement intervention (25 trials, 1195 participants) were less effective by the effect
    sizes (ES) of -0.384 (p = 0.004) and -0.419 (p = 0.028) respectively. However, compared to
    psychostimulant, PBT (19 trials, 1122 participants; ES = -0.308, p = 0.095) and combination of
    psychostimulant and PBT (7 trials, 441participants; ES = -0.196, p = 0.209) did not differ
    significantly. Conclusions Psychostimulant therapy surpassed non-stimulant pharmacotherapy and
    alternative/complement intervention. Psychostimulant therapy, PBT, and combination of
    psychostimulant therapy and PBT appear to be similar in efficacy according to this meta-regression.
    關聯: International Journal of Neuropsychopharmacology 24(10), p.776–786,
    DOI: 10.1093/ijnp/pyab034
    显示于类别:[數學學系暨研究所] 期刊論文


    档案 描述 大小格式浏览次数



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈