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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/120828

    Title: Exploring the Effects of Pharmacological, Psychosocial, and Alternative/Complementary Interventions in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: Meta-Regression Approach
    Authors: Kung-Han Yang;Yue-Cune Chang;Ruu-Fen Tzang;Hsien-Yuan Lane
    Keywords: ADHD;treatment efficacy;pharmacotherapy;behavior therapy;meta-regression
    Date: 2021-10-23
    Issue Date: 2021-06-07 12:10:21 (UTC+8)
    Publisher: Oxford University Press
    Abstract: Background Till now, there have been various therapies for attention-deficit/hyperactivity disorder
    (ADHD), but the previous meta-analysis of ADHD efficacy remains unclear. This study aims to
    systemically meta-regress the effect sizes of psychostimulant pharmacotherapy (methylphenidate and
    lisdexamfetamine), non-stimulant pharmacotherapy (atomoxetine and alpha-2 agonists), psychosocial
    therapy (parental behavioral therapy [PBT]), combination therapy (psychostimulant plus PBT), and
    alternative/complementary interventions to determine the right treatment for ADHD. Methods We
    searched various ADHD interventions from the MEDLINE and PubMed databases (National Center
    for Biotechnology Information) between January 1, 1980 and July 30, 2018. Following the meta-analysis of random effects, the meta-regression analyses were used to explore factors potentially
    influencing treatment efficacy. The confounding variables included type of treatment, type of study,
    age, type of symptom scale used, and year of publication. Results A total of 107 trials (N = 9883
    participants) were included. After adjustment, compared to the psychostimulant therapy (28 trial,
    2134 participants), non-stimulant pharmacotherapy (28 trials, 4991 participants) and
    alternative/complement intervention (25 trials, 1195 participants) were less effective by the effect
    sizes (ES) of -0.384 (p = 0.004) and -0.419 (p = 0.028) respectively. However, compared to
    psychostimulant, PBT (19 trials, 1122 participants; ES = -0.308, p = 0.095) and combination of
    psychostimulant and PBT (7 trials, 441participants; ES = -0.196, p = 0.209) did not differ
    significantly. Conclusions Psychostimulant therapy surpassed non-stimulant pharmacotherapy and
    alternative/complement intervention. Psychostimulant therapy, PBT, and combination of
    psychostimulant therapy and PBT appear to be similar in efficacy according to this meta-regression.
    Relation: International Journal of Neuropsychopharmacology 24(10), p.776–786,
    DOI: 10.1093/ijnp/pyab034
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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