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https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/120826
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题名: | Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model |
作者: | Huang, Guo-Shu;Peng, Yi-Jen;Hsu, Yu-Juei;Lee, Herng-Sheng;Chang, Yue-Cune;Chiang, Shih-Wei;Hsu, Yi-Chih;Liu, Ying-Chun;Lin, Ming-Huang;Wang, Chao-Ying |
关键词: | Chronic kidney disease;Magnetic resonance imaging;Musculoskeletal system |
日期: | 2021-05-11 |
上传时间: | 2021-05-14 12:11:02 (UTC+8) |
出版者: | Nature Research |
摘要: | The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague-Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, kel and kep) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability kep values from 16 weeks (p < 0.05), lower venous washout kel value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression. |
關聯: | Scientific Reports 11(1), 9924 |
DOI: | 10.1038/s41598-021-89336-8 |
显示于类别: | [數學學系暨研究所] 期刊論文
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