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    題名: Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
    作者: Huang, Guo-Shu;Peng, Yi-Jen;Hsu, Yu-Juei;Lee, Herng-Sheng;Chang, Yue-Cune;Chiang, Shih-Wei;Hsu, Yi-Chih;Liu, Ying-Chun;Lin, Ming-Huang;Wang, Chao-Ying
    關鍵詞: Chronic kidney disease;Magnetic resonance imaging;Musculoskeletal system
    日期: 2021-05-11
    上傳時間: 2021-05-14 12:11:02 (UTC+8)
    出版者: Nature Research
    摘要: The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague-Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, kel and kep) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability kep values from 16 weeks (p < 0.05), lower venous washout kel value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression.
    關聯: Scientific Reports 11(1), 9924
    DOI: 10.1038/s41598-021-89336-8
    顯示於類別:[數學學系暨研究所] 期刊論文


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