Synthesis of multiple boron-containing analogs via Ugi-4CR

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/120754

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題名:	Synthesis of multiple boron-containing analogs via Ugi-4CR
作者:	Chen, Yi-Wei;Liao, Pei-Chun;Zhang, Yu-Xuan;Yeh, Shang-Yi;Wu, Yu-Hsuan;Qiu, Shuo-Bei;Tsai, Pei-Ni;Xin, Zhuo;Ting, Yen-Yu;Chen, Hsien-Chi;Cheung, Siu-Fung;Hsu, Chen-Yun;Lien, Wan-Hsing;Pan, Po-Shen
關鍵詞:	Boron neutron capture therapy;Boron;Multicomponent reaction;Ugi reaction
日期:	2018-10-24
上傳時間:	2021-05-06 12:11:04 (UTC+8)
出版者:	Springer
摘要:	One of the most significant challenges in boron neutron capture therapy (BNCT) is to have an ideal boron delivery agent which can deliver sufficient numbers of boron atoms to designated tumor cells. In this work, mild synthetic conditions for synthesis of dipeptidyl multiple boron-containing analogs under microwave-assisted condition were investigated. The results showed that the reaction generally took place at 50 °C, but higher reaction temperature was required when a fluorinated building block was used. The resulting peptidyl skeletons generated by Ugi four-component reaction resemble basic cell metabolites and could potentially be used as alternative replacements for current boron carrier agents in BNCT.
關聯:	Research on Chemical Intermediates 45, p.103–118
DOI:	10.1007/s11164-018-3629-0
顯示於類別:	[化學學系暨研究所] 期刊論文

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