Positive Cyclin T expression as a Favorable Prognostic Factor in Treating Gastric Gastrointestinal Stromal Tumors

doi:10.3892/mco.2016.835

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/120057

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/120057

题名:	Positive Cyclin T expression as a Favorable Prognostic Factor in Treating Gastric Gastrointestinal Stromal Tumors
作者:	Lin, Lien-Fu;Jin, Jong-Shiaw;Chen, Jui-Chang;Huang, Chia-Chi;Sheu, Jeng-Horng;Chen, Wenlung;Tsao, Tang Yi;Hsu, Chih-Wei
关键词:	gastric gastrointestinal stromal tumor;cyclin T1;cyclin-dependent kinase 9;disease-free survival
日期:	2016-06
上传时间:	2021-03-05 12:14:30 (UTC+8)
摘要:	Positive transcriptional elongation factor b (P‑TEFb) contains the catalytic subunit cyclin‑dependent kinase 9 (Cdk9) and the regulatory subunit cyclin T. Cyclin T1 and Cdk9 are the key factors of the PTEFb pathways and are overexpressed in the human head and neck carcinoma cell line. However, there have been limited studies regarding the role of cyclin T1 and Cdk9 in gastric gastrointestinal stromal tumors (GISTs). The aim of the present study was to assess the association between cyclin T1 and Cdk9 and their clinical significance in gastric GISTs. A total of 30 gastric GIST patients who underwent either laparoscopic or laparotomic partial gastrectomy were enrolled in the study. The surgical tissue slides were stained with Cdk9 and cyclin T1 antibodies, and the immunohistochemistry scores and disease‑free survival (DFS) were analyzed. Ten patients were cyclin T1‑positive, and 20 were negative. All 11 patients with recurrent tumors or distant metastases were cyclin T1‑negative patients. Old age, large tumor size, a high Ki67 IHC staining score, high mitotic count and negative cyclin T1 staining revealed a worse clinical outcome in univariate analysis. By contrast, the Cdk9 score was not associated with clinical parameters. The Kaplan‑Meier survival curve illustrated that the DFS rate of the patients with negative cyclin T1 staining was significantly lower than that of the patients with positive cyclin T1 staining. Positive expression of cyclin T1 was a good prognostic factor in patients with gastric GISTs.
關聯:	Molecular and Clinical Oncology 4(6), p.971-975
DOI:	10.3892/mco.2016.835
显示于类别:	[化學學系暨研究所] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	47	检视/开启
Positive Cyclin T expression as a Favorable Prognostic Factor in Treating Gastric Gastrointestinal Stromal Tumors.pdf		458Kb	Adobe PDF	3	检视/开启

在機構典藏中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....