Differentiating Gastrointestinal Stromal Tumors from Gastric Adenocarcinomas and Normal Mucosae Using Confocal Raman Microspectroscopy

doi:10.1117/1.JBO.21.7.075006

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/120055

Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/120055

Title:	Differentiating Gastrointestinal Stromal Tumors from Gastric Adenocarcinomas and Normal Mucosae Using Confocal Raman Microspectroscopy
Authors:	Hsu, Chih-Wei;Huang, Chia-Chi;Sheu, Jeng-Horng;Lin, Chia-Wen;Lin, Lien-Fu;Jin, Jong-Shiaw;Chen, Wenlung
Keywords:	Raman spectroscopy;gastrointestinal stromal tumor;gastric adenocarcinoma
Date:	2016-07-11
Issue Date:	2021-03-05 12:14:27 (UTC+8)
Abstract:	Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and gastric adenocarcinomas are a common cancer worldwide. To differentiate GISTs from adenocarcinomas is important because the surgical processes for both are different; the former excises the tumor with negative margins, while the latter requires radical gastrectomy with lymph node dissection. Endoscopy with biopsy is used to distinguish GISTs from adenocarcinomas; however, it may cause tumor bleeding in GISTs. We reported here the confocal Raman microspectroscopy as an effective tool to differentiate GISTs, adenocarcinomas, and normal mucosae. Of 119 patients enrolled in this study, 102 patients underwent gastrectomy (40 GISTs and 62 adenocarcinomas), and 17 patients with benign lesions were obtained as normal mucosae. Raman signals were integrated for 100 s for each spot on the specimen, and 5 to 10 spots, depending on the sample size, were chosen for each specimen. There were significant differences among those tissues as evidenced by different Raman signal responding to phospholipids and protein structures. The spectral data were further processed and analyzed by using principal component analysis. A two-dimensional plot demonstrated that GISTs, adenocarcinomas, and normal gastric mucosae could be effectively differentiated from each other.
Relation:	Journal of Biomedical Optics 21(7), 075006
DOI:	10.1117/1.JBO.21.7.075006
Appears in Collections:	[化學學系暨研究所] 期刊論文

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