数据加载中.....
|
jsp.display-item.identifier=請使用永久網址來引用或連結此文件:
https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/120054
|
| 题名: | Novel Method for Differentiating Histological Types of Gastric Adenocarcinoma by Using Confocal Raman Microspectroscopy |
| 作者: | Hsu, Chih-Wei;Huang, Chia-Chi;Sheu, Jeng-Horng;Lin, Chia-Wen;Lin, Lien-Fu;Jin, Jong-Shiaw;Chau, Lai-Kwan;Chen, Wenlung |
| 日期: | 2016-07-29 |
| 上传时间: | 2021-03-05 12:14:26 (UTC+8) |
| 摘要: | Gastric adenocarcinoma, a single heterogeneous disease with multiple epidemiological and histopathological characteristics, accounts for approximately 10% of cancers worldwide. It is categorized into four histological types: papillary adenocarcinoma (PAC), tubular adenocarcinoma (TAC), mucinous adenocarcinoma (MAC), and signet ring cell adenocarcinoma (SRC). Effective differentiation of the four types of adenocarcinoma will greatly improve the treatment of gastric adenocarcinoma to increase its five-year survival rate. We reported here the differentiation of the four histological types of gastric adenocarcinoma from the molecularly structural viewpoint of confocal Raman microspectroscopy. In total, 79 patients underwent laparoscopic or open radical gastrectomy during 2008–2011: 21 for signet ring cell carcinoma, 21 for tubular adenocarcinoma, 14 for papillary adenocarcinoma, 6 for mucinous carcinoma, and 17 for normal gastric mucosas obtained from patients underwent operation for other benign lesions. Clinical data were retrospectively reviewed from medical charts, and Raman data were processed and analyzed by using principal component analysis (PCA) and linear discriminant analysis (LDA). Two-dimensional plots of PCA and LDA clearly demonstrated that the four histological types of gastric adenocarcinoma could be differentiated, and confocal Raman microspectroscopy provides potentially a rapid and effective method for differentiating SRC and MAC from TAC or PAC |
| 關聯: | PLoS ONE 11(7), e0159829 |
| DOI: | 10.1371/journal.pone.0159829 |
| 显示于类别: | [化學學系暨研究所] 期刊論文
|
文件中的档案:
| 档案 |
描述 |
大小 | 格式 | 浏览次数 |
|---|
| index.html | | 0Kb | HTML | 51 | 检视/开启 | | Novel Method for Differentiating Histological Types of Gastric Adenocarcinoma by Using Confocal Raman Microspectroscopy.pdf | | 1059Kb | Adobe PDF | 23 | 检视/开启 |
|
在機構典藏中所有的数据项都受到原著作权保护.
|
