Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/120053

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題名:	Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease
作者:	Huang, Chia-Chi;Isidoro, Ciro
關鍵詞:	Alzheimer's disease;amyloid-β peptide;brain tissue;diagnosis;Raman spectroscopy;tau protein
日期:	2017-04-19
上傳時間:	2021-03-05 12:14:24 (UTC+8)
摘要:	The continuous increasing rate of patients suffering of Alzheimer’s disease (AD) worldwide requires the adoption of novel techniques for non-invasive early diagnosis and monitoring of the disease. Here we review the various Raman spectroscopic techniques, including Fourier Transform-Raman spectroscopy, surface-enhanced Raman scattering spectroscopy, coherent anti-Stokes Raman scattering spectroscopy, and confocal Raman microspectroscopy, that could be used for the diagnosis of AD. These techniques have shown the potential to detect AD biomarkers, such as the amyloid-β peptide and the tau protein, or the neurotransmitters involved in the disease (e.g., Glutamate and γ-Aminobutyric acid), or the typical structural alterations in specific brain areas. The possibility to detect the specific biomarkers in liquid biopsies and to obtain high resolution 3D microscope images of the affected area make the Raman spectroscopy a valuable ally in the early diagnosis and monitoring of AD.
關聯:	Journal of Alzheimer's Disease 57(4), p.1145-1156
DOI:	10.3233/JAD-161238
顯示於類別:	[化學學系暨研究所] 期刊論文

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